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    The technology boom of the ‘90s romanticized the “rags-to-riches” ideal that all of us dream about when investing. Fo
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    r those that invested $1000 in Dell at $5 during 1990, held through the seven splits, then sold in March 2000 at $59,
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    he dream was a reality. That investment would have returned an amazing $1,132,800! Image making over $1 million for
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    every thousand dollars invested. Beyond Dell, companies like EBay, Amazon.com, and many others made their investors v
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    ry wealthy.

    Unfortunately, the ‘90s provided a different investment environment than we are use to. We experienced t
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    e birth of a new technology and it required new companies, jobs and consumers to fill the needs of the industry. Imme
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    diately, our economy had a new demand with limited supply. This led to the feeding-frenzy stock purchasing that we al
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    witnessed.

    Once reality settled in, too many companies were heavily leveraged, over-extended in equity, and/or did n
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    ot have revenues to support their business models. The sudden collapse of mega-companies like Webvan, the online groc
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    r that wasted over $750 million, became highly responsible for the economic problems that we faced earlier this centur
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    .

    Moral of this story: Invest to make money, not to get rich.

    One lessoned learned during the ‘90s was the importan
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    ce of due diligence; researching company financial records, management philosophies, growth strategies, etc. Doing so
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    allows investors to find strong investment opportunities and minimize the risk of purchasing a bankrupt company.

    Inve
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    sting to make money stresses the need to evaluate financial goals and taking steps, not leaps, to get there. The oil
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    oom of the year has brought about several high return stocks; doubling or tripling in a matter of months. Taking adva
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    tage of one of these stocks is a giant leap, but finding a 200% gain might require 7-8 25% losses. Ultimately, an inv
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    estor could lose more than gained.

    With solid research, finding companies capable of returning 10-20% growth per year
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    has a high probability. While not as romantic as a single high-return investment, five 20% gains equals the return of
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    a single 100% gain. This is the meaning of taking steps. Settle for solid returns and repeat the process as many ti
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    es possible. While not every stock will produce 20%, selecting strong companies will limit your risk for large losses


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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