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Mortgage payments are scheduled for the borrowers periodically by their lenders. There are many mo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

rtgage payment options available for borrowers in North Carolina. They can choose from bi-weekly,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

i-monthly, or regular monthly payment options.

Bi- weekly payments allow the borrowers to divide

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

heir monthly payments into two parts, paying them two times a month. This implies that, instead of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

paying the full amount once a month, the borrowers pay half of their scheduled monthly mortgage p

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

yment after every two weeks. The main advantage of this option is that borrowers repay an amount e

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ual to thirteen monthly payments by the end of the year, instead of the usual twelve. This allows

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the borrowers to pay off their mortgages faster and will save a lot of money on interest. As the m

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rtgage is being paid off sooner, borrowers are able to build on their equity just as fast.

Bi-mon

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

hly payment plans are different than the bi-weekly plan. Two monthly payments are combined into o

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

e single payment that is paid every other month. pay off their mortgages only one month before the

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

stipulated time, so there is not much interest saving in this plan. Therefore, it is not a very p

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

pular plan among the borrowers in North Carolina.

Regular monthly payments are the usual equated

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

onthly installments that borrowers have to pay towards mortgage. These payments are calculated on

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the basis of the term of the mortgage, amount of the mortgage and the rate of interest applied tow

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

rds it. This means that for a fifteen-year term, borrowers will have to make 180 monthly payments.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Borrowers also have an option, to make extra payments every month towards the principal of the mo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rtgage. Most of the mortgage companies allow this option, however, it is advisable to check the mo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

tgage document if there are any fees applied.

Borrowers can use payment calculators available onl

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ne to determine the amount of payment for each option and also the savings offered by them, if any

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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