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Some time ago, I had some problems with the first commercial property I purchased. The tenant's business failed, and due

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

to some mistakes I made, he still owed me quite a lot of money. I learnt many lessons from this deal, and in this artic

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

le I will share one of the most important...

Lesson 1: Don't Trust People To Get Back To You...

Because this was my fi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

st commercial real estate investment, and because it was an out-of-town investment, I decided to use a local property

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

manager. At first, things seemed to be going well, but I began noticing some discrepancies in the figures. The tenan

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

was getting a bit behind in the rent.

I called the property manager, but he wasn't in. I told the secretary the detail

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s, and was told the manager would get back to me.

Two weeks passed, with no reply.

At this stage you're probably ask

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ng, How did I let 2 weeks go by?

Well, for me, real estate investing is not my full time activity. I have a lot of othe

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

r things I do in my life, and real estate investing is not my top priority. So when I was told the manager would get

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

back to me, I took it out of my mind, and got on with my normal day-to-day living, expecting him to get back to me.

I

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t was only 2 weeks later, when something triggered my memory, that I thought to ring back and see what was happening.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

This same problem happened several times, sometimes with more than a month passing before I remembered to chase thing

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

up again.

Now, you might say that the problem here was with the property manager, not me, and that I should drop the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

property manager on the spot.

I agree that this is grounds for changing the property manager, but in my experience,

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

his sort of behaviour is quite common in the real-estate world. Tenants, Property managers, tradesman... very few of t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

hem get back to you at the time when they promise they will.

So the lesson I learned was to NOT expect them to call b

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ck when they say they will. Make a note in your calendar on the date the are supposed to reply, and call them back i

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

f they haven't. Or, if you want a more powerful solution, do a online search for "Tickler File", as these are a great

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ay of tracking this sort of thing.

The important lesson is to take responsibility for things getting done. Don't leave

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

your investment at the mercy of someone else, and don't expect people to do what they say. Remember: it's your money

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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When you sign up for an affiliate program or some form of revenue sharing plan have you ever wondered if you could offer an affiliate program yourself? You don't need to be a geek to do it and this first of a two part series explains how you can.

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