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Today we rarely see pictures of famine in our television sets and it is only the sub-Saharan region of Africa that stills endures them. However, up until the nineteenth century, even E

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

urope was experiencing them with some regularity. As recent as the 1840s, the potato famine in Ireland killed a million persons and forced two million more to emigrate. As for Russia,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

its last famine was in the 1930s and it killed about thirty million peasants. Other regions of the world have been more unfortunate. In the nineteenth century, China lost about sixty m

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

illion people to famine and as recent as the 1960s thirty million more died.

The further we go back in time, the more recurrent were the scenes of starvation. Up until the eighteenth

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

century, all nations of the world were regularly enduring famine and malnutrition.

The massive abundance of food of today is all the result of science and technology. It is farm machi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nery, fertilizers, and processed food that ones that have transformed a world of hunger into one of plenty.

For centuries however, whenever hunger struck, people all over the world pr

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ayed to their respective Gods, but those Gods never delivered an eatable thing.

Famine has been one of the major killers of people, easily outstripping wars. However, the amount of pe

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ple that have died as a result of starvation has been small in comparison to the ones that have perished as a result of diseases.

Famines nonetheless, have been more damaging than wha

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

t the raw figures suggest. The fact is that the low supply of food that prevailed through history was ultimately responsible for the majority of the deaths resulting from diseases.

Du

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ring the thousand years that constitute the Middle Ages in Europe for example, famine was recurrent but it did not occur every year. What did happen every year was malnutrition because

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

the supply of food was always low. Malnutrition has devastating effects on the human metabolism because it weakens the immune system and thus opens the door to many opportunistic dise

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ases.

Since all religions have been constantly conspiring against science and literally killing the scientists, it is clear that the main reason why humanity experienced so much hunge

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

r for so many centuries was because of the mentally-lethargic policies of the Church. Had technology not been curtailed, sooner would have motorized reapers, computerized harvesters, a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nd many other productivity-enhancing agricultural goods appeared.

The men of faith have always opposed not just science, but also education. That ultimately, also had nefarious effect

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

on progress because the larger the share of the population that receives an education, the larger the amount of men that become inventors.

Religions always have it easier when a popu

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

lation is illiterate and ignorant. Under those circumstances, nobody contests their vision of the world, which is so filled with inconsistencies. That is why they have always accused t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

he learned of being instruments of the Devil.

Interestingly enough, it was the men of faith who actually brought onto humanity the very things they claimed the Devil would bring onto

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

society. As a result of their science-hindering policy, the four horses of the apocalypse (pestilence, war, famine, and death) fell for thousands of years over all nations of the world

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

. The evidence suggests that it is them who have done the work of the Devil and not the intellectuals.

History shows that religion is responsible for the billions of deaths that throu

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

gh time resulted from famine and disease. Since it is also responsible for practically all the wars of history, it is evident that the number one enemy of humanity is the belief in God

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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