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"The good thing about being a man: You don't give a rat's ass if no-one notices your new haircut. Gray hair and wrinkles add character." ~ Anon

The first time Alex and I went to Rod, our new hairdresser, I

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

followed Alex to the chair and started giving my opinion on how his hair should be cut. Rod immediately cut me off saying: it is his hair, how about the two of us decide what looks good according to his want

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

?

Of course, he was very diplomatic as not to offend me, but I immediately caught the clue and asked him about this very topic. I told Rod I was writing this book and needed to know more about this subject.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

He told me that he feels sorry for the guys who come in with their girlfriends and they insist that their men have a certain hair cut. Men being the pleasing types they are, immediately comply.

I then kept

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

thinking about dress style and so on and what I have imposed my taste on my partners. It is so very true that not only I, but many of us, make our men have the appearance we want them to. For instance, I lik

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

mustaches. Well, all my men had a mustache when we were together. To my husbands, I would buy them clothes I liked. It was always a matter of "educating" them to what looked good on them, regardless of what

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

they thought would look good on them.

I had a friend who was the nicest looking man in the city where we lived (to my taste, of course). He used to wear dress pants, nice shoes, great shirts, suspenders, a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

d a bow-tie. A bow-tie! That was incredibly charming. He told me that he was not always like that and that his girlfriend had taught him how to dress. Way to go, woman!

Granted, most men have no clue how to

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

dress appropriately. They truly need help. I wonder why their mothers never taught them that, or perhaps, they never learned. There are many books on the subject, or, perhaps, there should be a course in co

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lege: "Appearance 101: How to look good," where they would learn about colors, styles, etc. My biggest pet peeve about men"too many of them to ignore" is the eternal cap they insist upon wearing, that is so

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

nbecoming and prevent us from looking them in the eyes.

Speaking of cap, in all my classes, I used asked my students to remove their hats so I could see their eyes. Some of them resented that, but they all

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

complied. One student was very resistant but seeing that it was a good move to obey me, he did so. His hair looked unraveled, of course; his appearance was not that impressive either: he was overweight and s

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

oppily dressed. Well, next class, I noticed that his hair was different. He had cut it. Then, slowly, I noticed a significant change in his appearance. By the end of the 15 week semester, he had lost 30lb, h

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ad bought new clothes, looked absolutely stunning, and found a nice girlfriend. Not to mention that he got and "A" in the course. Now, is this a good story or what? And just because I insisted he removed his

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hat in class. He was absolutely grateful and thrilled. And so was I.

I am now teaching my son that first impressions count tremendously and that he shall always strive to look his best: hair, clothes, shoes

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

teeth, ears, grooming, etc. Yet, it seems that there is another faulty gene here (or is it in every man?) for many times he is totally inappropriate: the other day, he wanted to go to the opera wearing clot

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hes that were 100% uncoordinated and tennis shoes! Gasp! Of course, I had him change but not without a little apprehension about my limiting his self expression.

Now, this said and done, we must understand

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hat, ultimately, the way a man dresses needs to be entirely up to him. If we don’t like it when we meet them, we will not like them later on. We can always try to coax them into something more appropriate; h

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

owever, if he doesn’t comply, we need to lower our expectations or close our eyes.

A Word of Advice Ladies: Hints do not work. If you think your man does not dress appropriately, tell him so and give many

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

uggestions always respecting his opinion on about what feels good and comfortable. Buy him a book with many pictures.

Gents: Listen to your woman’s suggestions but be the one to decide what you want to wear

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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This World War II combat veteran discusses some of the major battles fought during the Pacific War, battles in which he participated. None were needed to defeat Japan. Our nation has long needed to apologize, with shame, to all who fell in battles that should not have been fought, or who went to battles led by incompetent commanders, or those who were worse.

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