Suggest - Relationships

Romantic relationships, much like people, have a developmental lifecycle. We aren’t often aware of where our relationships are in terms of their developmental stages, but being aware can

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

be extremely helpful in interpreting the shifts in dynamics that occur over time between us and our partner.

In a sense it’s true that relationships have a life of their own. Each deve

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

opmental stage in the relationship has its own set of thoughts, feelings, behaviors, and developmental tasks. These relationship stages are analogous to childhood, adolescence, and adult

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ood in people’s developmental lifecycle.

Youth – The Honeymoon Stage

The earliest, youngest stage of a relationship is an intensely romantic, passionate time. In this

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

stage we feel so deeply connected that we become emotionally merged. During this stage, often called the honeymoon phase, we see our partners as being perfect and as completing us and sa

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ving us from experiencing old emotional wounds or pain. Likewise they believe that we’re perfect and complete them. What could feel better than being with someone who thinks we’re perfe

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

t in every way, especially if we haven’t received that kind of unconditional adoration at any other time in our lives!?

John Gottman, researcher and therapist who has studied couples for

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

over 20 years, has found that couples who stay in touch with how they felt about each other during this honeymoon phase weather the inevitable relational storms better than couples who l

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

se touch with their experience of this time. I think of the developmental task of young, romantic love as cementing the relationship and establishing a foundation that will support the r

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

elationship across the years.

Adolescence – The Disillusionment Stage

The second stage of relationships begins when we start to recognize that our partners are imperfec

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

human beings and that they don’t complete us or protect us from being emotionally hurt. In fact, they more often seem to target the very areas of emotional pain we expected them to save

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

us from. At the same time they start to recognize that we’re not perfect and seem to be irritated or angry with us about that.

The disillusionment of this stage can be very painful. It

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

can be experienced as scary or as a betrayal or as a fall from grace. Often anger, bitterness, and resentment rule during this time. Couples can get stuck in this place or the relations

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

hip may not survive it at all.

However, if you think of this stage as the adolescence for the relationship it can put the painful dynamics into perspective. Adolescence is a time to bec

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

me a separate and independent individual. For a relationship to be strong, healthy, and functional it needs to be supportive of two separate, individuated people. When we give up signif

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

cant parts of ourselves to the relationship, generally we suffer and as a result the relationship suffers. Thus, although becoming unmerged can feel excruciating at times, it is an impor

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ant step in the evolution of the relationship.

Adulthood – The Fulfilling Stage

The third stage or adulthood in a relationship provides a structure that supports and no

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

urishes two differentiated people. This requires that we be committed to our own as well as our partner’s wholeness as individuals and that we be committed equally to the relationship.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

his stage can feel challenging around finding balance among the three entities – two individuals and the relationship. It also requires a maturity around being able to own and manage our

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

own emotional insecurities and reactivity. However, this phase is the most rewarding and is the time when we can be authentically connected while living with integrity to our true selves

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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One of the most difficult situations to deal with in short sale investing is, in fact, the vacant property. An empty home does not mean an investment is impossible. It can, however, be a bit complicated. What is so dangerous about this type of investment is the misconception that a vacant property is fair game to any investor who comes along.

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