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As human beings, we all have an innate need to be close to someone. But sometimes the very thing we desire is the opposite of what we have. Some of us subconsciously sabotage the relationships we want because of our fear of intimacy. Sometimes we unknowingly and unwillingly drift apart because of our inabilit

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

y to engage in the delicate dance of intimacy. Others avoid intimacy altogether because the pain of past failures is too great.

Intimacy, physical and emotional closeness, is tough to navigate our way through. It takes skill, hard work and commitment. I wish I could tell you it is easy once you know how. Tr

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ue intimacy is tough to achieve, but who says the best gifts are easy to obtain? In all honesty, I am certainly no expert on how to maintain and nurture closeness, but I have learned 11 things that will definitely kill intimacy in a relationship.

Dishonesty and Silence
Intimacy requires honesty and openne

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ss. It only takes one lie to destroy the trust in a relationship. To be close to someone, we need to be able to share what is true and real about us. And we must be willing to hear someone else's truth. Sometimes we think that it is best to not say anything at all if it means it may hurt our partner. So we

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

silently hang on to our truth or share our truth with the wrong people. When we do this, there is no opportunity for the relationship to grow with integrity.

Lack of Trust
Sometimes there is no dishonesty in the relationship, but still a lack of trust exists. Perhaps healthy trust has never been a part o

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

f your life, or maybe a painful event in life has fractured your ability to trust. A person must heal from their past and base their decision to trust someone on the present actions of a person. Deem people trustworthy until proven otherwise.

Desire to Change People
True intimacy necessitates acceptance.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Having acceptance of yourself and your partner is a powerful indicator of love. It doesn't mean you have to like everything, but you need to let go of the need to change another person. When we lack acceptance of another person's qualities, our tendency is to control. That control manifests itself in disapp

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

roving feelings, and sometimes even pressuring people to change. To feel close to another person, you must feel unconditionally accepted for who you are.

Inability to Express Your Needs and Feelings
Unfortunately we, as humans, do not have the power to read minds. Therefore, we have to rely on our partne

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rs to communicate with us and vice versa. It is each person's responsibility to express their needs and feelings. By sharing who we are and what's important to us, we significantly increase our chances of having our needs met. On the other hand, if we repress our needs and feelings, we shut the other person o

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ut of our world, and make intimacy impossible.

Not Listening
Communication is a two-way street. Many of us have no problem talking, but listening poses more of a challenge. Listening requires us to hear our partners with our heart. An added step to listening is acknowledging what we have heard. Are you

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

really hearing your partner's feelings and needs? Or are you thinking about how your partner is wrong or how you want to defend yourself? If your partner is constantly communicating the same need or feeling to you over and over, chances are you are not hearing your partner with your heart.

Self-Centeredness

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

r> The minute you decide to enter into a committed relationship, the moment self-centeredness becomes a thing of the past. Intimacy requires there to be a balance between self, the other person and the relationship. It's not about just you anymore. You have to take the feelings and needs of the other person

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

and the relationship into consideration. Decisions about money, routines, free time, children, time, etc. now have to include your partner's input.

Lack of Respect
Chances are if you lack respect for your partner, your intimate life probably suffers. To respect means you hold a high opinion and highly va

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

lue yourself or another person. You appreciate and show consideration for people. The closeness of intimacy needs a general feeling of respect for self and your partner. It also means you need to behave in a way that deserves respect. You cannot expect your partner to respect you if your actions do not warra

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

nt respect.

Imbalance of Power
There cannot be one person in a relationship that sees him or herself as more important than his or her partner. A relationship consists of two people with perceived equality. That doesn't mean one person isn't smarter, more knowledgeable about certain topics, or has greate

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

r strengths in certain areas. It means the difference is not highlighted, flaunted or disrespected. Having a balance of power requires each person to have equal say in a discussion. It means the needs and feelings of each person are equally important.

Unhealthy Arguments
All couples have disagreements.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

The intimacy in your relationship will suffer if you let your arguments get out of hand. Angry words, unresolved arguments, and inflicting emotional and physical pain will destroy intimacy. Couples that are close learn how to respectfully and healthily resolve their arguments.

Absence of Touch
Although

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

physical intimacy is just a part of total intimacy, it is a very important part. If you don't make a point to hug, kiss, and experience sexual intimacy, your level of intimacy will be affected. You can still be close, but touch adds extra feelings of warmth, safety and love.

Extreme Separateness
So many

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

couples, after time, begin to live separate lives. Either their differences separate them or unawareness or lack of intention cause them to drift apart. Intimacy requires people to spend time together and share in each other's life. A relationship is like a garden. You need to take the time to pull the weeds

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

, fertilize and water the flowers. In other words, it requires time, love, and a commitment to keep the bad to a minimum.

If you want your relationship to be intimate, love and respect one another, do your best to meet one another's needs, share your dreams and feelings, and avoid these eleven intimacy killers

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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