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    Several years ago I was in a San Diego restaurant with my mother. While I paid the check, we both noticed an elderly woman waiting to be seated. As we left the restaurant, Mom asked, "Did you notice that woman with the wonderful smile?" I most certainly did. Her smile lit up the room. It was a smile to die for; one that would certainly win instant friends. It wa
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    s a smile that you don't often see in a stranger. And maybe Mom and I smiled back, I don't remember. Mom later commented, "I wish I'd told her what a terrific smile she had." But neither of us had. We'd both received a gift without saying thank-you.

    Later, on my long drive home, I stopped at a fast-food restaurant for a quick bite. A 70ish woman waited by the c
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    ndiment bar while her husband ordered. She glanced my way and smiled brightly. It was one of those smiles that broadcast, "I love life!"

    I wasn't going to let THIS opportunity pass. I was going to say SOMETHING. As I approached this woman from 30 feet away, her smile melted into a rather startled look; as if asking, "Did I do something wrong?" I walked over to
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    her and simply said, "You have a wonderful smile!" Wow, did her face light up! And she responded with an enthusiastic, "Thank You". My comment probably made her day, but it also made MY day. We truly exchanged gifts that afternoon.

    SMILES: INSTANT FACELIFTS

    Life's lessons have taught me this: a smile is the number one feature that makes people attractive. It'
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    a welcome mat. It's what makes folks approachable. People with a great smiles radiate a warmth that draws others to them instantly.

    Some people naturally have a great smile. Others, analytical types like me, must work at it. One way to tell if you're in my category is to recall picking up your developed photos. As you flipped through the pictures, you didn't l
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    ike the way you looked in most of them. But then...you discovered that one great picture of yourself. In it, you look friendly, you're smiling broadly and your eyes twinkle. Now THAT picture looks like you!

    I hate to say it, but ALL the pictures look like you, even those you dislike. Unfortunately, those "bad" photos, where your face doesn't look its best, port
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    ay how you often appear. In fact, you might normally look even worse, since you were TRYING to look good for the camera. Usually you're not even making that effort, and may appear even less inviting than you do in "bad" photos. And if you're like me, you assume you're not particularly photogenic and that your smile needs work. When you've mastered your smile, yo
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    u'll consistently look better in photos. Most important, though, you'll be more attractive and approachable every day.

    When you're having a good time, does your face show it? You might be surprised. Years ago I dropped into a comedy club in Montgomery, Alabama. I was sitting in the front row, where one is typically fair game to be picked on by the comedian. But
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    being the non-expressive, serious Norwegian that I am, I wasn't giving the comic the jovial feedback he needed. I was enjoying the show, but in a straight-faced manner. About halfway through the show, the comic interrupted his routine to ask me point-blank, "Are you having a good time?" I responded, "I'm having a great time." His comeback: "Well then, tell your
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    face!" I was enjoying the program, laughing inside, even studying the performer's humor and technique. BUT...not giving him any outward indication.

    In everyday life the same concept applies. You might be enjoying your job, but fail to show it. You may want to meet someone, yet not give them a single, friendly clue. You can even be IN LOVE with somebody, and tot
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    lly hide it. Your face should express what you feel when you wish to connect with others.

    SMILE AEROBICS FOR EMOTIONAL HEALTH

    One way to become better at smiling is increasing your awareness. Take notice of those you find warm and inviting. Is it their smile? Make an effort to LOOK for great smiles. Notice the appeal of people who smile with their EYES, not ju
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    t their mouth. The whole face gets involved. Consider these people your models. Study yourself in the mirror. How do you look in the rest room, when shopping, and while passing a reflective window? Do you look friendly? Approachable? Do you really LIKE the image you're projecting?

    In fact, a mirror is ideal for your smile workout. Practice various smiles toward
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    capturing that perfect look for the camera. Work on expressing your smile with your eyes. A tip: cut a paper rectangle that permits you to see only your eyes in the mirror. Practice smiling just with your eyes. Get used to the feel of your cheekbones as they lift to brighten your eyes. When you see how a great smile LOOKS, remember how it FEELS. When you can fi
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    ally project your best smile, hold it. Turn away from the mirror. How does your face feel? What muscles are you using? Make an effort to develop muscle memory, so you can instantly recreate this smile at will.

    THE SMILING REMINDER

    Sometimes it's life's little reminders that help us focus on making self-improvements. I set out to find a "smile" lapel pin as a p
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    ermanent token of my smile's importance. After a fruitless one-year search, I commissioned the design and production of smile pins. Now when I encounter a total stranger with a million-dollar smile (not an everyday occurrence), I share the compliment, "You have a wonderful smile...thanks for brightening my day! I'd like you to have my golden smile pin." Then I m
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ght add, "And someday, when YOU see a total stranger with a fantastic smile, you can pass on the pin to them."

    This little reminder has conditioned me to search out life's glowing smiles, and not to allow them to pass unnoticed. I always carry "golden smile" pins. And when I spot a show-stopper smile, I always express my appreciation.

    Other strategic pluses:

    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    1. The pin reminds me never to leave home half-dressed: without my smile. Even while I'm running routine errands, it keeps me focused on smiles as life's true blessings.

    2. By shaping my focus, the pin increases awareness of my public appearance and attitude. For example, when in a grocery line, I don't want the checker to glance up and think, "Why in heaven's
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    ame is this sourpuss wearing a smile pin?" It forces me to wear a friendly face all day.

    3. The pin encourages me to compliment others. When I fail to say a kind word about someone's beautiful smile, I feel guilty. Now, that's what I call constructive guilt! We've often been conditioned to feel shame because we've not lived up to what others expect, but isn't i
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    t more positive to suffer guilt for failing our OWN expectations?

    You needn't search for a smile pin to remind you. You can choose another object, like a clown pin, that will program you to focus on smile power. Or consider something that nobody else sees, like whimsical underwear. In fact, you may discover that the sheer strength of just your awareness can cre
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    te positive life changes. With practice you can focus on life's smiles; and create your own relaxed, naturally warm smile. And THEN when you get back a roll of photos, you'll like almost all of them! That's certainly been my pleasant experience. And when you encounter customers, strangers, or loved ones, you'll always be ready to pass on your award-winning smile


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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