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In a good relationship, we pay compliments to each other all th

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e time. We love receiving positive feedback and try to go out o

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

our way to let our partner know how happy we are to be with th

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

m. But verbal remarks fade so quickly. Make them last by puttin

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

them in writing where they can be revisited later to re-trigge

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

r their positive response.

There's no need to write long love

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

etters as in the past. A scrawled phrase "Thanks so much for la

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

t weekend, it was beautiful" on a greeting card generates plent

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

of warm feelings in the receiver. A quick e-mail "Thursday's d

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

inner reminded me of our first big date at ________ and I was a

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

excited as a teenager" will be stored in a personal folder for

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

a later re-read when spirits are low.

Sentiments expressed in

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

riting carry more weight because we are all programmed through

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

years of education to believe and respect the written word so m

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ch more than a verbal remark that fades in passing and is often

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

not completely remembered.

A favorite catch phrase: "All this

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ime and you're still the one," "All these years, and we're stil

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

l having fun," or "Let's keep on trucking for a lifetime," can

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ecome a shorthand method of communication between the two of yo

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

that expresses all you mean to each other in a few short words

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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