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Do we know what dreams mean? Science has few definite answers. They may be a way to exercise the brain and keep it functioning well. Scientists say that dreaming might be a way to categorize

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

and "file away" things that weren't sufficiently dealt with during the day. That would explain why daily events are often a part of dreams that night.

It does appear that dreaming is necessa

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ry. When researchers prevent people from dreaming by waking them up whenever they start dreaming (as evidenced by their REM or "rapid eye movement," which accompanies dreaming), it causes men

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tal distress, although this was often shown in nothing more than increased attempts to dream. People who are woken an equal number of times, but randomly, didn't seem to suffer as much.

Bott

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

om line? We may need to dream, but we don't know why. Also, we could argue endlessly about the meaning of the content of our dreams. But despite no certain knowledge about what dreams mean, w

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e do know that there are ways we can use our dreams.

What Dreams Can Mean: Entertainment

Perhaps you occasionally have a dream that is better than most movies you've seen. You may n

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ot even want to wake up from some dreams, because they are so enjoyable. Would you like to have more dreams like these?

Perhaps you can, by waking up IN the dream, and taking control of it.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Fly over that lake or join that party. Do what you want, because you can direct your dream if you know that you're in a dream. This is the idea behind lucid dreaming.

Does lucid dreaming wor

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

k? Many people say they regularly are conscious and in control during their dreams. I know that I've had more than one dream where I argued with someone that we were in a dream - and of cours

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e I proved it by waking up. We could argue about what consciousness is, but it is still easy to see how much fun you could have with such "controlled dreams."

To induce lucid dreams, some us

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

a "trigger" that reminds them they are dreaming. This can be a common object you're likely to see in a dream - a clock, for example. Every time you see a clock, you say "I am dreaming right

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

now and can do what I want." Make this a habit, and you are likely to say it when you see a clock in a dream, thus "waking yourself up" to the fact that you're in a dream. At this point you c

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

an take control and have some fun with your dream.

What Dreams Can Mean: A Chance To Solve Problems

I've had many good ideas come to me in dreams. In fact many of my web site pages

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

started out as dreams. For creative ideas or to solve problems in your dreams, try some of the following.

1. First do some mental work in the area you want ideas or a solution. Think about i

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

t for a while, write some notes down, and consider some solutions. This preliminary work signals the brain that the topic or problem is important, so it will continue to work on it below cons

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ciousness.

2. Turn off your alarm clock. When you wake up naturally, you are more likely to remember what happened in your dream.

3. Have a recording device or a pen and paper next to your

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

bed. Make a note on any ideas you have if you wake up in the night, and especially when you first wake up in the morning.

4. When you first wake up, lay still and review your dreams for a mo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ment. This "sets" them in your mind, so you won't forget them as easily as we normally do. Then you can think back on them later, to search for any useful ideas that showed up.

Most of these

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

techniques are not scientifically "proven." But having had lucid dreams, I can tell you that they are at least entertaining, and having used numerous techniques to get good ideas from dreams

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

- and always with more success than when I do nothing - I am convinced that there is some value in this playing with our dreams, whether or not we ever completely understand what dreams mean

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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