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Many people would like to have whiter teeth, but for whatever reason, whether it be money, time, or worry, don’t want to go t

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

o the dentist to have a professional tooth whitening treatment performed.

And while I recommend that you go to the dentist f

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

r the best possible whitening treatment, there are some other options that you may like to consider… if you really don’t want

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

to go through the hassle of going to the dentist.

One of these options is the “paint on your teeth” whitening products that

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

are available on the market today. These can be quite effective, especially compared to similar products like tooth whitening

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

strips.

One of the advantages of using a paint on product, is that you don’t have to use the dental trays, which some people

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

can find quite uncomfortable. As the name suggests, all you have to do is apply the product directly to your teeth. Another

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

dvantage this gives you is the ability to apply it to only a few teeth, if you only have a few teeth that you feel need white

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ing.

Some of the paint on products even contain the same chemicals that you find at the dentist. This chemical is called car

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

bamide peroxide, and it is a whole lot more effective than hydrogen peroxide, which is commonly used in cheaper products like

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tooth whitening strips.

So what types of paint on tooth whitening product are there? Well, you have two main choices. The fi

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

st choice is the “all night” type of product. With this, the chemical is put on before you go to bed, and left to do its work

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

through the night. This can have good results, because the chemical has quite a few hours to work.

The other option is to u

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e a product that is on your teeth for less time. Usually 30 minutes to an hour. These tend to be not as effective as the all

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ight ones, but they still get good results. So it’s down to personal preference for which one you decide to go with.

Some pr

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

oblems that people have with the paint on products are that the “paint” can come off the teeth quite easily. You may or may n

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t have a problem with this. If you eat or drink during the time that the product is applied, then it may come off very easily

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

It’s designed to come off when you brush your teeth, so it doesn’t take much to dislodge the paint.

Now if you decide to tr

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

y out paint on tooth whitening products, I wish you luck. But remember that the best option is always to go to the dentist an

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

have a professional tooth whitening treatment performed. Although it is more expensive, it’s much quicker and more effective

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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There are some of the questions you should be asking yourself before you make a decision. Hopefully, this list can give you some more insight on the important factors you need to consider beforehand.

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