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First of all, I'm not a doctor or therapist. I just have spent most of my life learning from them, to undo the effects of major depression that I've had from childhood. If you suffer f

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

rom depression, first talk to your medical professional to see what approach is best for you. That is what I've done, but I add to what I've learned by trying a few other things on my

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

own. Don't do anything to yourself that is potentially self-injurious, it pays to research any new technique or approach thoroughly, just to be safe. Whatever works for me may not work

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

for you, we all have our own ways of responding to different treatments. I just know that not all my recovery has come from what was learned at the doctor's office. Being exceptionall

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

y strong-willed, my mission has mainly been to boost self-esteem, and fight those inner feelings of sadness that never go away (effects of depression.) Here are some ways that have hel

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ped me live a productive and successful life, despite mental challenges.

Six months ago, it was necessary for me to go for physical therapy for a slipped disk in my back. The therapis

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

t hooked me up to a small machine called a TENS unit, for one of my treatments. They put small, non-invasive sticky circles (electrodes) on the part of my body needing therapy and then

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

turned the machine on. It felt really good, sort of like a massage. Depending upon how the therapist adjusted the dials, the machine would make knocking or pinging sensations on my ba

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ck. There are also knobs to adjust the intensity of each sensation. After researching the TENS unit on the internet, I ordered a small one, about the size of a deck of playing cards.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

According to what I read about them, TENS machines are not only good for distracting your body into feeling good sensations rather than pain, but they can make your body produce endorp

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ins, or feel-good chemicals, too. This intrigued me, since having depression, I'll take all the feel-good anything I can get (as long as it is both moral and legal.) So, I set up to te

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

st this on myself and see if there was any merit to the theory. After years of taking various anti-depressants, some work more than others but none completely take away depression, in

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

my experience. Not being a scientist or doctor, I read up on everything about the TENS machine. There are rules that come along with the machine, like not putting the electrodes on the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

head, neck or the heart areas. Make sure to follow all of them thoroughly. People with pacemakers should not use TENS units, because it can interfere with the way they work. As with m

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

edicines, ask your doctor before using one.

By placing the electrodes along my spine, and setting the TENS settings to the recommended low frequency (pulse) levels. You want low muscl

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e contraction, and to use the TENS for approximately 20 to 40 minutes. If you set it for higher muscle contractions, your muscles may ache later, so I rely on what the experts say, to

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

use it at low settings. For more detailed information, I found these sites helpful:

http://www.bootsmaternityrentalproducts.co.uk/abouttens.php http://www.medcareservice.com/Pain-Con

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

trol-Mechanism-Article.cfm

Using the TENS unit has helped my overall mood, it seems, as after using it, my demeanor is calm and relaxed. Though I don't know if this is due to the mach

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ine itself or not, but I believe that using it has helped me. Combined with other treatments, this TENS therapy is assisting me (along with other techniques for reducing depression) in

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

making a more enjoyable life. Go ahead and research TENS units online, and see if this is something suitable for you. In my point of view, it is a viable way to help combat depression

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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