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Let us set about understanding ‘pranayama’ and meditation after we drew down our expectations from them. Some people expect the impossible from these. The uninformed anticipations like diabetes cure or ‘kevela kumbhaka’* (do not worry what it is, at this stage) helping to defy death, bring disre

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

spect to this simple, pristine health practice. It is not a path to salvation or god.

1. Pranayama and meditation help in bettering your breathing, hypertension and respiration ailments.

2. Pranayama invigorates internal organs to function as they are designed to. E

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ample: lungs and heart.

3. Pranayama along with meditation helps gain control over mind and thus able to concentrate more.

4. Important of all, it calms down arousing thoughts and frustrations.

The tendency to call pranayama a technique should be refrained at. The word te

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

chnique dilutes the practice to something, like a ready made formula that when applied, results in a quick fix solution. Yet it is known to have resulted in helping patients suffering ailments like asthma and palpitations. But it is not an out of the box, all-in-one remedy.

What is Pranayama

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

/b>?

It is a conjoin of two words prana and ayama. Prana stands for breath and ayama for dimension. This is not the same dimension as in measurement. So, pranayama is a conscious and definite way of breathing for expected results. The breathing cycle in pranayama can be divided into three ste

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ps.

1. Puraka

2. Kumbhaka

a. Antar-kumbhaka

b. Bahya-kumbhaka

3. Rechaka

Inhalation or puraka of breath is slow enough to feel the air filling your lungs and alveoli to their entirety. In the normal course we do not feel this as our breaths are shallow. Here in practicing pranayama,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

we make an attempt to fill in completely & deeply and see lungs expand to maximum. We watch the inhalation to be peaceful from beginning till we are full.

Exhalation or rechaka is again equally slow as the inhalation is and we should watch that it is complete. With this we feel the empty lungs

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

contracting to minimum.

Retention or kumbhaka has two varieties such as internal retention or the ‘antar-kumbhaka’ and the external retention or ‘bahya-kumbhaka’. The former is important as it gives our alveoli time sufficient enough to exchange the oxygen the puraka has brought in and the excretes li

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e carbon dioxide and moisture back to breath. Notice, without the breath being retained at least for a while inside our lungs, we will not be making justice to our own selves.

The normal volume of air handled per cycle of breathing is measured and is around 200 – 300 ml. But with the watchful a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

nd conscious pranayama, it is found to increase upto 500 ml in healthy adults.

Method of pranayama practice

The excerpts of methodology explained in good books and perfected over the centuries by proponents are here for you. Here is a tip to you before you are begun with the practice. Prana

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ama is something to start with a firm faith in it. Do not take it just for the heck of a dekko (trial). Here we go!

Practice to chant ‘OM’. The sound of OM can be divided tripartite.

1. ‘?’ (should sound like the first syllable in the word audit)

2. ‘oo’ (this is the sound as in the word shoot)

3. ‘m

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

(the simple, mouth closed sound)

When and how long one should chant this? The chant OM may last for 10 to 12 seconds depending on time you take to inhale or exhale fully. You can prolong this further, looking at your comfort level. Mind you, do not unnecessarily stretch time till you suffocated. Comfort lev

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

el is important here. You are not doing hatha yoga with this.

Divide the stretch of time equally amongst the three components of OM.

Get the feel by placing your palm on your diaphragm when you start chanting ? and move up to mid chest during oo, finally touch the top of your lung when chanting m.

Repeat t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e same thing, but in reverse order when exhaling (rechaka).

You can hold your breath approximately for the same duration as the inhalation and exhalation (i.e; incase of antar-kumbhaka). This is the most important time physiologically as well as mentally. This is when the actual exchange of the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

oxygen and waste gases occurs. Observe this meticulously in a silent environment.

You can practice this in sets of twelve and increasing the number of sets to comfortably more than three, with increase in experience. If you are doing more than one set, I would suggest you to use your nostrils alterna

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ely for inhalation and exhalation. Further for increasing concentration, you can try closing your eyes during the course of pranayama.

In the silence of your surrounding, under guided breathing you realize your heart beat has eased up even from the normal rate, giving it th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e much desired rest. The heart pumps blood slowly but rich with oxygen. This is studied to be beneficial even psychosomatically. The relaxation of the muscles leads to lesser energy consumption calming the brain.

Now, what do you make of meditation? I tend more to think it is just the other face of th

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

same coin as pranayama is, wherein you guide your mind and breathing and control certain metabolic activities. If there is any difference, then it can be just in what you chant. Thank you.

* kevala kumbhaka – only kumbhaka. There is no puraka or rechaka.

Katha Upanishad (I. iii. 3 to 6)

The soul is

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

like a traveler who has set on a journey of life in the chariot of the body, driven by the intellect (buddhi) with the mind for the reins and the sense organs being the horses. The objects of experience form the way to be traversed. The soul, senses, and mind together form the enjoyments of pleasure and pain

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

i.e., the individual. If the mind is not properly controlled, then the senses go out of hand like untrained horses. But if the mind is properly controlled then the senses obey the orders of the master, i.e., the individual, like well trained horses. Indeed, such an individual reaches the highest goal of life

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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