Suggest - Health and Fitness

The mangosteen (Garcinia mangostana) is a tropical evergreen tree, believed to have originated

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

in the Sunda Islands and the Moluccas. The tree grows from 7 to 25 meters tall. The rind of the

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

edible fruit is deep reddish purple when ripe. The fragrant flesh is sweet and creamy, citrusy

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ith a touch of peach flavor. In Asia, the mangosteen fruit is known as the "Queen of Fruits." I

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t is closely related to other edible tropical fruits such as button mangosteen and lemondrop ma

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

gosteen.

Many people describe Mangosteen, a remarkably delicious fruit, as the most luscious f

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

uit in the world. Mangosteen contains xanthones, which occur naturally in various organic comp

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ounds. Xanthones are extracted from the rind, or the pericarp. Xanthones are considered to hav

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

antioxidant properties that help to protect the body from the harm associated with free radica

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s. In TriFusion Plus, we’ve added an additional 20 percent pericarp to enhance the antioxidant

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

enefits in every serving.

Mangosteen fruit contains mangostinone, tannins, and epicatechin, an

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

important bioflavonoid. Epicatechin may improve dilation of blood vessels, circulation, and bl

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

od flow, and has been used to support heart health. Mangosteen pulp also contains vitamins and

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

inerals, including calcium, phosphorus, iron, thiamine, riboflavin, niacin, and vitamin C.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Mangosteen has been reported to help address the following health challenges:

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

vents hardening of the arteries

Protects the heart muscle

Anti-Parkinson, Anti-Alzhei

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

er and other forms of dementia

Anti-Depressant

Anti-fungal

Prevents bacteria inf

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ections

Prevents gum disease

Anti-diarrheal

Lowers fever

Prevents glaucoma

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nd cataracts

Weight loss

Lowers blood fat (Anti-lipidemic)

Encephalitis

Low

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

rs blood pressure

Lowers blood sugar

Reduces inflammation

Reduces pain

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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