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A major element in building a healthy relationship is trust. Without it, the relationship will not develop and grow. Trust can b

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e a scary thing to do and it is not always easy to accomplish. This is the case when we have experienced many negative responses

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

and feelings through the course of our life.

Learning to trust is the most important lesson of childhood. If we do not learn to

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

rust we spend our lives feeling uncertain within relationships. We invest our energies into holding back our feelings and keeping

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

our feelings on guard. This leaves us feeling unhappy and alone.

Sometimes we may trust but only after the other person has pro

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ven himself trustworthy. The other person often resents being tested while we hold back to make certain of their intentions. If

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e cannot trust others, we will not be trusted. We can never know for sure. We are always changing and growing.

We can only trus

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

t for the moment. We cannot say that we trust someone forever because we can never know what tomorrow will bring. If we trust th

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

at someone or something will always be or that something will never happen we are being unrealistic. To trust is to risk being hu

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

t and there will always be some risk involved. In relationships we can expect to grow at separate paces and hope the relationship

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

will begin to meld together.

We know that trust is important for a good, healthy relationship but trust is often something we ha

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ve learned not to do. One of the best ways a couple can build trust in each other is to talk about their fears and difficulties w

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

th trust. By acknowledging our reservations about trust we are better able to make a commitment to work on trust.

Here are some

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

suggested topics on trust

1. We will not abuse each others feelings and we allow each other to express them.

2. We will allow ea

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ch other to be ourselves without being judgmental.

3. We will be honest and direct with each other.

4. We will strive to be cons

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

stent in what we think, say, and do.

5. We will not willfully hurt each other. We cannot always know what will hurt each other,

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

but if it happens, we will discuss ways to resolve and prevent it.

6. We will respect each others privacy. We will not share eac

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

h others secret outside our relationship.

7. We will be committed to each other to the level in which we have agreed to be.

Trus

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

can mean whatever a couple decides it means to them. Building trust takes time and deserves patience. Our “don’t trust” pattern

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s are usually longstanding so it takes practice to overcome them. Trust often builds slowly but eventually we will learn to trust

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Westerners believe opposites flow in a natural cycle always replacing the other. They tend to look at things as black or white, right or wrong, up or down, giving a separation and unrelated-ness in ...

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