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“They were not at all ashamed, nor could they blush ….” (Jeremiah 6:15 Amplified OT).

I think we have finally and forever fulfilled this verse. When I see a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nd hear what is going on in this world, I marvel that God has waited so long to clean our clocks. I recall my beloved grandmother expressing great disgust at

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

a certain ad back in 1958. Yikes, she should see them now--she would do double-time back to her grave.

The prayer of Ezra, the scribe, the brave, good, holy

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

man who led a company of his Israelite brethren from Babylon to Jerusalem, prayed for his sinful nation, “O my God, I am ashamed and blush to lift up my face

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

to Thee, my God.” Perhaps we need the shepherds of our wandering-in-the-wilderness flocks to do more praying and less compromising with the ever-lowering sta

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

dards of this bewildered planet which is sinking in strange theories and even-stranger practices.

The following is from the Biblical Illustrator, Author Unk

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nown:

"BY WHAT WAYS [WE] COME TO CAST OFF SHAME AND GROW IMPUDENT IN SIN:

1. By the commission of great sins. For these waste the conscience, and destroy a

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

once. They are, as it were, a course of wickedness abridged into one act, and a custom of sinning by equivalence. They steel the forehead, and harden the he

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rt, and break those bars asunder which modesty had originally fenced and enclosed it with.

2. Custom in sinning never fails in the issue to take away the se

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

se and shame of sin, were a person never so virtuous before. First, he begins to shake off the natural horror and dread which he had of breaking any of God’s

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

commands, and so not to fear sin; next, finding his sinful appetites gratified by such breaches of the Divine law, he comes to like his sin and be pleased wi

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

th what he has done; and then, from ordinary complacencies, heightened and improved by custom, he comes passionately to delight in such ways. Finally, having

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

resolved to continue and persist in them, he frames himself to a resolute contempt of what is thought or said of him.

3. The examples of great persons take

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

way the shame of anything which they are observed to practice, though never so foul and shameful in itself. Nothing is more contagious than an action set off

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

with a great example, for it is natural for men to imitate those above them, and to endeavor to resemble, at least, that which they cannot be.

4. The observ

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

tion of the general and common practice of anything takes away the shame of that practice. A vice a la mode will look virtue itself out of countenance, and i

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t is well if it does not look it out of heart too. Men love not to be found singular, especially where the singularity lies in the rugged and severe paths of

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

Virtue.

5. To have been once greatly and irrecoverably ashamed renders men shameless. For shame is never of any force but where there is some stock of credi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

to be preserved. When a man finds that to be lost, he is like an undone gamester, who plays on safety, knowing he can lose no more."

Diogenes said to a you

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

h whom he saw blushing: “Courage, my boy, that is the complexion of virtue.” The mind of Christ will give us the complexion we so need in these shameful days

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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