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Some time back, a writing assignment comes on my way. It's about providing small biographies of some 1000-odd personalities. The place to look for information,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

my assigner tells me, is the venerable Wikipedia. The job needs me to refer Wikipedia day in day out, and I'm overawed more than ever by the richness of resourc

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

s it offers.

Prior to this, I did have occasional peeks at it, but those were mere skimming the surface. The more I now dig into Wikipedia, the more I become c

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

onvinced that there's no other resource quite like it, not perhaps even the ubiquitous Encyclopedia Britannica. When my son's school asks him to do his project

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ork with the help of Wikipedia, I know for sure it is the numero-uno place for serious information-seekers. Little wonder then that it is the 17th most visited

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

site globally.

What it is that is so enticing about Wikipedia? It doesn't need my telling, f

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

r I'm sure my readers will have pretty good knowledge about it. Instead, I'll focus on some lesser-known aspects that, put together, speaks a lot eloquent about

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

it.

Wikipedia has nearly a million articles in English language alone, the total of which represents just about one-third of total contents. It caters to at l

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ast 48 languages, each of which having not less than 10,000 articles.

Wikipedia depends on some 2000 to 3000 strong core community that has taken upon itself t

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

o voluntarily maintain and improve it. It's they who do most of new content addition in English as well as corrections and modifications of existing matter as n

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

eded.

Though necessarily an open source venture, Wikipedia does not earn revenues from any ad-network. It does not display any ad on its pages, which is quite

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

emarkable, because if it does so, it will not need to depend on voluntary contribution, which is usually around $50 to $100 each.

Wikipedia's budget is modest

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

compared to the volume it caters to and the service it offers. Its 2005 budget was $750,000 and this year it's likely to be $1.5 million, a clean 100% jump. But

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

that without doubt is required because it wants to find ways to improve quality of contents that is better than Britannica, and of course add more and more fres

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

h contents. Besides, there may be other revenue-generating plans. For example, extracting articles on request from its repository to be sold in print or DVD/CD.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

The one factor that is truly worth watching is how its contents stand up on contentious issues. This is where neutrality emerges out of pushes and pulls of the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

community members. So be it Iraq War or the infamous World War II holocaust, Wikipedia has them all with no scope for circumventing the truths. Just this quali

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

y makes it the most unique one can imagine and a treasure-trove of information hunters (or, shall I say truth-seekers) worldwide.

By now, if you think Wikipedi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

a has to a big organization, you are mistaken. For all that it offers, apart from Jim Wales, the founder, Wikipedia has only 4 more full-time staff on its rolls

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

a CEO, a manager and 2 programmers, one in US, the other in Australia. Quite a feat that for a site fetching close to 48,000 visitors everyday, don't you think

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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